It's husband No. 3 for actress Kate Winslet

NEW YORK (AP) — Kate Winslet has tied the knot again.

The Oscar-winning actress wed Ned Rocknroll in New York earlier this month. The private ceremony was attended by Winslet's two children as well as a few friends and family members, her representative said Thursday.

It is the third marriage for the 37-year-old Winslet. She was previously married to film directors Jim Threapleton and Sam Mendes.

The 34-year-old Rocknroll, who was born Abel Smith, is a nephew of billionaire Virgin Group founder Richard Branson.

The couple had been engaged since last summer.

Winslet won a Best Actress Oscar for her performance in the 2008 film "The Reader."

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Books: From Bang to Whimper: A Heart Drug’s Story

On June 23, 2005, American medicine managed to take a small step forward and a giant step backward at precisely the same time, with government approval of the first medication to be earmarked for a specific racial group. It was BiDil, a drug designed to treat heart failure in blacks.

Enthusiasts hailed BiDil’s approval by the Food and Drug Administration as a landmark event in the nascent field of pharmacogenomics, which aims to create drugs tailored to fit an individual’s genetic makeup as precisely as a bespoke suit drapes its owner’s shoulders. Critics just winced and clocked one more misstep in medicine’s long history of race-related disasters.

You would think that the elucidation of the human genome would have cleared up most of the hoary untruths surrounding race and health. But as Jonathan Kahn makes clear in his worthy if convoluted review of the events surrounding the birth of BiDil, the genome has in many respects only made things worse.

It has been clear for decades that race has minimal relevance to the body’s inner workings. Research has repeatedly shown that the biologic variations among individuals of the same race are reliably great enough for race to retain little utility as a biologic predictor. You might as well sort people by height. Or, in the words of an editorial writer for Nature Biotechnology in 2005, “Pooling people in race silos is akin to zoologists grouping raccoons, tigers and okapis on the basis that they are all stripy.”

But old misconceptions die hard, particularly for entrepreneurs eagerly awaiting cash bonanzas from the genomic revolution.

Race may be irrelevant; it may be, as Dr. Francis Collins, the director of the National Institutes of Health, put it, “a weak and imperfect proxy” for genetic differences. But it is also a familiar concept — and asking people what race they are is substantially cheaper than genotyping them.

So in a peculiar paradox, race has come to serve in some circles as a crude surrogate for genetic analysis until actual genomic medicine comes along — a temporary bridge from now to later, known to be flawed but still a quasi-legitimate stand-in for the real thing.

Against this background unfolds the story of BiDil, a drama of greed and good intentions.

Several observations prompted the drug’s development. Among them was the common assertion from the last century that blacks with heart failure were more likely to die than whites. (Mr. Kahn does an impressive job of researching and debunking this statistic.) Then there was the belief that blacks often reacted badly to some of the newer drugs used for treating heart failure, and the results of a study dating from the 1980s suggesting that many black patients did well with two old standby drugs.

Those two drugs were (and are) on sale as generics, costing pennies a pill. But just suppose they were combined into a single pill that could be then specifically marketed to patients who just happened to be thought in particular need of effective medication? Now there was a pharmacologic and marketing plan that would extend a lucrative new patent for decades.

And so it came to pass that a collection of eager investors and some of the nation’s foremost cardiologists smiled on the results of an industry-sponsored trial performed on self-identified black subjects with heart failure: The two cheap drugs combined into the not-so-cheap BiDil reduced mortality by 40 percent compared with placebo. This figure was impressive enough to end the trial early and speed BiDil to market.

How did whites do on BiDil? Nobody bothered to check.

Mr. Kahn deserves credit for teasing out all the daunting complexities behind these events, including the details of genetic analysis, the perils of racial determinations and the minutiae of patent law. Unfortunately, though, he suffocates his powerful subject in a dry, repetitive, ponderous read.

A law professor with a doctorate in history and longstanding interest in race issues, Mr. Kahn trudges a partisan path through the drama in which he himself was a player. (He testified before an F.D.A. advisory committee that BiDil should be approved without racial qualifications.)

He heads bravely into many statistical thickets, but omits relevant clinical data; he repeatedly refers to the trial that led to BiDil’s approval, for instance, but I could find its numerical findings nowhere in the book and had to look them up. In a story that fairly drips with potential human interest, he offers the reader not one sip.

The issues raised on every page are so important and so thought-provoking that it would be irresponsible to warn interested readers away. Still, it would be almost as irresponsible to misrepresent the difficulty of the journey.

As it happens, BiDil itself has had a remarkably inglorious career. Despite its much-trumpeted release, patients did not request the medication, and practicing doctors did not prescribe it.

NitroMed, the company that developed it, sponsored no further studies and failed in 2009.

The drug still lingers on the market; Mr. Kahn writes that BiDil may be resurrected in sustained-release form — that other time-honored technique for wringing a few more years from a drug’s patent.

For a parable of early 21st-century medicine, as it treads water between past and future and never hesitates to reach for a buck, it doesn’t get much better than BiDil.

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White House urges end to labor fight at East, Gulf Coast seaports

The Obama administration is urging union dockworkers and a management group to "continue their work at the negotiating table to get a deal done as quickly as possible" to avoid a strike that could idle 14 East and Gulf Coast seaports.

The word that President Obama is keeping a close eye on the ports' labor situation came from Obama spokesman Matt Lehrich.

The labor union -- the International Longshoremen's Assn. -- and a group known as the U.S. Maritime Alliance are closing in on the end of a 90-day contract extension. The extension ends at midnight Saturday.

The alliance is made up of several shipping lines, terminal operators and port associations.

If no agreement on a new contract is reached, a strike could begin as early as Sunday. It would be the first strike by the ILA in 35 years.

As many as 14 major seaports and 14,500 union workers would be affected. But a group of retailers, manufacturers, farmers and other interested parties have said that the effects of such a strike on the nation's economy could be devastating. The vast majority of the nation's imports and exports move by sea.

U.S. military shipments and so-called bulk cargo that is not carried in 20-foot to 40-foot-long steel cargo containers would not be affected. But more than 50% of the nation's containerized import goods sold by U.S. retailers would be affected. A large portion of the country's agricultural exports would also be impacted.

On Thursday, there was no new developments to report on the state of the negotiations.

Earlier in the week, George H. Cohen, director of the Federal Mediation and Conciliation Service, issued a statement saying that both sides had agreed to meet. The statement said that "due to the sensitive nature of the negotiations," there would be "no additional comment at this time."

John Husing, an economist and founder of the Redlands firm Economics and Politics Inc., said the biggest issue of contention involves so-called container royalty fees on cargo, which supplement dockworker wages. Employers want to cap those fees and limit who gets them. The union says the royalty fees should not be changed.

The ILA says it represents 65,000 dockworkers on the East and Gulf coasts as well as on several major U.S. rivers and the Great Lakes and in Puerto Rico and Eastern Canada.

The impact of a strike would be mitigated by one thing: This is the slowest season for cargo coming by sea into the U.S. Shippers have usually moved their goods for the busy holiday retail season by October.

Even so, a "failure to reach a contract agreement would result in a coast-wide shutdown at 14 containerized ports -- from Maine to Texas -- which would have serious economy-wide impacts," the retail federation and coalition of national and state organizations said in a letter sent to Obama.

Late last month, most of the Port of Los Angeles and half of the Port of Long Beach were shut down during an eight-day strike by the clerical unit of the International Longshore and Warehouse Union.

The ILWU, which represents West Coast dockworkers, is not affiliated with the ILA.

Meanwhile, management at three of the four grain terminal operations at ports in the Pacific Northwest have given union dockworkers what they call their final contract offer.

A strike or a lockout at those terminals would strand millions of dollars of U.S. agricultural exports destined for sale overseas.

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Obama, Democrats, winning over public on 'fiscal cliff'

WASHINGTON -- Americans are increasingly doubtful that Congress and the White House will reach a budget deal as the deadline to the "fiscal cliff" approaches, according a new poll, though more said they still think a compromise will eventually be formed out of the fight.
 
According to Gallup, just 50% of those polled said they think President Obama and Congress are at least somewhat likely to reach a budget compromise, down from a high of 59% on Dec. 9. An increasing number, 48%, said they see no resolution before a deadline of Jan. 1.
 
The cliff, that self-imposed deadline set in place last year to force a deal on government expenditures and revenues, would institute broad spending cuts across government programs and allow President George W. Bush's tax cuts to expire. Both Republicans and Democrats have offered evolving proposals on how to avoid both actions.

PHOTOS: Notable moments of the 2012 presidential election 

But as they have sparred back and forth, with House Speaker John Boehner's "Plan B" proposal notably failing prior to the shutdown in Washington for the Christmas holiday, Obama and his allies appear to be coming out on top, at least in the court of public opinion as measured by Gallup.
 
A majority of survey respondents, 54%, said they approve of the way that Obama has handled the negotiations, and 45% said they approve of Democratic leaders in Congress. Just 26% said they approve of Boehner and the Republican congressional leadership.
 
That's a sharp increase for Obama and the Democrats, 6% and 11%, respectively, since Gallup's last round of polling Dec. 15-16. Approval ratings for Boehner and the Republicans remained low, increasing by 1 point for the House speaker and decreasing by 3 points for his colleagues.
 
A majority of respondents, 68% to 22%, also said they favor compromise over strict adherence to principles in the budget negotiations.

QUIZ: How much do you know about the fiscal cliff? 

Obama is scheduled to return to Washington by midday Thursday to restart negotiations, cutting short his holiday vacation to Hawaii. He will be met by the House and Senate, which are reconvening after the holiday, though neither chamber has any specific legislation laid out on their schedules.

The poll was conducted between Dec. 21 and 22 via telephone interviews with 1,076 people, with a margin of error of +/- 4 percentage points.

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Ticket rush: Film fans hand Hollywood record cash

LOS ANGELES (AP) — The big deal for Hollywood is not the record $10.8 billion that studios took in domestically in 2012. It's the fact that the number of tickets sold went up for the first time in three years.

Thanks to inflation, revenue generally rises in Hollywood as admission prices climb each year. The real story is told in tickets, whose sales have been on a general decline for a decade, bottoming out in 2011 at 1.29 billion, their lowest level since 1995.

The industry rebounded this year, with ticket sales projected to rise 5.6 percent to 1.36 billion by Dec. 31, according to box-office tracker Hollywood.com. That's still well below the modern peak of 1.6 billion tickets sold in 2002, but in an age of cozy home theater setups and endless entertainment gadgets, studio executives consider it a triumph that they were able to put more butts in cinema seats this year than last.

"It is a victory, ultimately," said Don Harris, head of distribution at Paramount Pictures. "If we deliver the product as an industry that people want, they will want to get out there. Even though you can sit at home and watch something on your large screen in high-def, people want to get out."

Domestic revenue should finish up nearly 6 percent from 2011's $10.2 billion and top Hollywood's previous high of $10.6 billion set in 2009.

The year was led by a pair of superhero sagas, Disney's "The Avengers" with $623 million domestically and $1.5 billion worldwide and the Warner Bros. Batman finale "The Dark Knight Rises" with $448 million domestically and $1.1 billion worldwide. Sony's James Bond adventure "Skyfall" is closing in on the $1 billion mark globally, and the list of action and family-film blockbusters includes "The Hunger Games," ''The Twilight Saga: Breaking Dawn — Part Two," ''Ice Age: Continental Drift," ''Madagascar 3: Europe's Most Wanted," ''The Amazing Spider-Man" and "Brave."

Before television, movies were the biggest thing going, with ticket sales estimated as high as 4 billion a year domestically in the 1930s and '40s.

Movie-going eroded steadily through the 1970s as people stayed home with their small screens. The rise of videotape in the 1980s further cut into business, followed by DVDs in the '90s and big, cheap flat-screen TVs in recent years. Today's video games, mobile phones and other portable devices also offer easy options to tramping out to a movie theater.

It's all been a continual drain on cinema business, and cynics repeatedly predict the eventual demise of movie theaters. Yet Hollywood fights back with new technology of its own, from digital 3-D to booming surround-sound to the clarity of images projected at high-frame rates, which is being tested now with "The Lord of the Rings" prelude "The Hobbit: An Unexpected Journey," shown in select theaters at 48 frames a second, double the standard speed.

For all of the annoyances of theaters — parking, pricy concessions, sitting next to strangers texting on their iPhones — cinemas still offer the biggest and best way to see a movie.

"Every home has a kitchen, but you can't get into a good restaurant on Saturday night," said Dan Fellman, head of distribution for Warner Bros. "People want to escape. That's the nature of society. The adult population just is not going to sit home seven days a week, even though they have technology in their home that's certainly an improvement over what it was 10 years ago. People want to get out of the house, and no matter what they throw in the face of theatrical exhibition, it continues to perform at a strong level."

Even real-life violence at the movie theater didn't turn audiences away. Some moviegoers thought twice about heading to the cinema after a gunman killed 12 people and injured 58 at a screening of "The Dark Knight Rises" in Colorado last summer, but if there was any lull in attendance, it was slight and temporary. Ticket sales went on a tear for most of the fall.

While domestic revenues inch upward most years largely because of inflation, the real growth areas have been overseas, where more and more fans are eager for the next Hollywood blockbuster.

Rentrak, which compiles international box office data, expects 2012's foreign gross to be about $23 billion, 3 percent higher than in 2011. No data was yet available on the number of tickets sold overseas this past year.

International business generally used to account for less than half of a studio film's overall receipts. Films now often do two or even three times as much business overseas as they do domestically. Some movies that were duds with U.S. audiences, such as "Battleship" and "John Carter," can wind up being $200 million hits with overseas crowds.

Whether finishing a good year or a bad one, Hollywood executives always look ahead to better days, insisting that the next crop of blockbusters will be bigger than ever. The same goes this time as studio bosses hype their 2013 lineup, which includes the latest "Iron Man," ''Star Trek," ''Hunger Games" and "Thor" installments, the Superman tale "Man of Steel" and the second chapter in "The Hobbit" trilogy.

Twelve months from now, they hope to be talking about another revenue record topping this year's $10.8 billion.

"I've been saying we're going to hit that $11 billion level for about three years now," said Paul Dergarabedian, a box-office analyst for Hollywood.com. "Next year I think is the year we actually do it."

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Online:

http://www.hollywood.com

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Study Finds Modest Declines in Obesity Rates Among Young Children From Poor Families

A new national study has found modest declines in obesity among 2- to 4-year-olds from poor families, a dip that researchers say may indicate that the obesity epidemic has passed its peak among this group.

The study, by researchers from the Centers for Disease Control and Prevention, drew on the height and weight measurements of 27 million children who were part of the federal Women, Infants and Children program, which provides food subsidies to low-income mothers and their children up to the age of 5.

The study was based on data from 30 states and the District of Columbia and covered the years from 1998 to 2010. The share of children who were obese declined to 14.9 percent in 2010, down from 15.2 percent in 2003, after rising between 1998 and 2003. Extreme obesity also declined, dropping to 2.07 percent in 2010 from 2.22 percent in 2003. The study was published Tuesday in The Journal of the American Medical Association.

The report defined a 3-year-old boy of average height, almost 3 feet 2 inches tall, as being obese when he weighed 37 pounds or more. The same boy was categorized as being extremely obese when he weighed 44 pounds or more.

“The declines we’re presenting here are pretty modest, but it is a change in direction,” said Heidi M. Blanck, one of the study’s authors and the acting director of the Division of Nutrition, Physical Activity and Obesity at the disease centers. “We were going up before. And this data shows we’re going down. For us, that’s pretty exciting.”

The findings were another sign that one of the nation’s seemingly intractable health problems may be reversing course, at least among children. Single interventions like school exercise programs have not worked, and public health experts now say that only a broad set of policy measures has a chance of success.

Over the past year, several major cities, including Los Angeles, New York and Philadelphia, have reported obesity declines among some parts of their student populations.

The new study was one of the first to document a national decline in obesity among young children from low-income families. Researchers say that is particularly meaningful in a population that is disproportionately at risk. Twenty percent of poor children are obese, compared with about 12 percent of children from more affluent families, according to the centers.

It is unclear what drove the decline, but Dr. Blanck offered hypotheses. Breast-feeding, which often leads to healthier weight gain for young children, has increased since 2000. The percentage of 6-month-olds still being breast-fed increased to 47.7 percent among children born in 2009, up from 34.2 percent among children born in 2000.

Breast-feeding of infants from low-income families has risen over the years. In 1980, only 28 percent of infants from those families had ever been breast-fed, compared with 66 percent in 2011.

Dr. Blanck also pointed to changes in the environment, like those documented in a report about food marketing practices released by the Federal Trade Commission on Friday.

The agency found that the amount of money spent on food marketing to children declined by nearly 20 percent from 2006 to 2009, with the biggest drop in television advertising. The total spent on food advertising to youths in 2009 was $1.79 billion, the report said.

The report, based on data from 48 major food and beverage marketers, also found that cereals marketed to children ages 2 to 11 had about a gram less sugar per serving in 2009 than in 2006 and slightly more whole grain.

Marketing to children of the most sugary cereals — those with 13 grams or more sugar per serving — was virtually eliminated between 2006 and 2009, according to the report.

But drinks marketed to children still averaged more than 20 grams of added sugar per serving, the report found. Most of the improvements in beverages in the time period were in those sold in schools, the report said.

Dr. Blanck said she was hopeful that several national programs begun in the past few years would help extend the early declines. One initiative, Let’s Move! Child Care, initiated by Michelle Obama’s office, helps child care centers serve healthier food and include physical activity throughout day.

Changes in the foods that are subsidized in the Women, Infants and Children program, like less financing for fruit juice and more for fruits and vegetables, may also help, she said.

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Hedge fund manager Whitney Tilson also shorts Herbalife

Another hedge fund manager is joining Bill Ackman in the ranks of Herbalife haters.

Whitney Tilson, who helps run three hedge funds and two mutual funds through T2 Partners, said in a mass email Wednesday that he’s short “a tiny smidge” of Herbalife and other so-called multilevel marketers who sell products through individual distributors.

Herbalife, the Los Angeles provider of health supplements, has seen its stock tumble 40% in four trading days after Ackman last week accused the company of operating as a pyramid scheme.

Ackman, the head of Pershing Square Capital Management, said he was shorting, or betting against, Herbalife and laid out his allegations in a detailed presentation in New York.

Tilson’s email message called Ackman’s argument “the most remarkable piece of investment analysis I have ever seen. Simply astonishing,” according to ValueWalk.

In the missive, Tilson wrote that he hopes Ackman’s campaign against the multilevel marketer “results in massive reform of this whole sector, which has preyed upon MILLIONS of vulnerable people all over the world for decades.”

In the last 52 weeks, Herbalife shares have lost about half of their value. Most of that plunge came after Ackman’s attack. In Wednesday trading, however, the stock was recovering, up as much as 8.8% to $28.35 a share.

Herbalife said last week that it will wait until next month to respond to Ackman’s allegations.

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Problems with new 787 Dreamliner continue to plague Boeing

Aerospace giant Boeing Co. just can't seem to escape trouble with its new 787 Dreamliner passenger jet.

More than three years late because of design problems and supplier issues, the much-anticipated plane has run into another bout of turbulence with fresh concerns about its safety.

The Federal Aviation Administration this month ordered inspections of fuel line connectors on Dreamliners because of risks of leaks and possible fires.

PHOTOS: Inside the Dreamliner

On the same day, a United Airlines Dreamliner flight from Houston to Newark, N.J., was diverted to New Orleans after an electrical problem popped up mid-flight. After accepting delivery of the aircraft just a month earlier, Qatar Air later said it had grounded a Dreamliner for the same problem that United experienced.

Despite criticism of the problem-plagued program, Boeing is confident that the plane will be a success once it gets more miles under its wings.

"We're having what we would consider the normal number of squawks on a new airplane, consistent with other new airplanes we've introduced," Boeing Chief Executive Jim McNerney said in an interview on cable network CNBC.

"We regret the impact on our customers, obviously," he said. "But … we're working through it."

The Dreamliner, a twin-aisle aircraft that seats 210 to 290 passengers, is the first large passenger jet with more than half its structure made of composite materials (carbon fibers meshed together with epoxy) instead of aluminum sheets. Major parts for the plane are assembled elsewhere and then shipped to Everett, Wash., where they are "snapped together" in three days, compared with a month the traditional way.

Chicago-based Boeing says the new plane burns 20% less fuel than other jetliners of a similar size. Because of this, the plane has been hotly sought-after. Through November, Boeing had delivered 38 Dreamliners.

The company has taken 844 orders for the plane from airlines and aircraft leasing firms around the world. Depending on the version ordered, the price ranges from $206.8 million to $243.6 million per jet.

Early customers get massive rebates on the first planes delivered because of bugs that may pop up in production. The plane maker sells these early aircraft at a loss.

David E. Strauss, an aerospace analyst at UBS Financial Services, said in a note to investors this month that his analysis indicates Dreamliner production "costs are not declining rapidly enough for [Boeing] to come close to its target for break-even 787 cash flow by early 2015."

Boeing spokesman Chaz Bickers said he would not comment on Strauss' analysis, but he did say that the company had already cut its production cost per plane by half. He did not specify how much that was.

"We're very pleased on the progress and confident on our processes," he said. "Once we get to 10 Dreamliners a month and stay there, that's when we expect a healthy production system."

Boeing is currently making five Dreamliners a month. The company doesn't plan on reaching 10 a month until late next year.

Many of the planes so far have gone to Japanese carrier All Nippon Airways, which has 16 of them. The airline said the Dreamliner has exceeded its expectations.

Since All Nippon began flying the planes in November 2011, it has flown nearly 7 million miles and saved 21% more fuel per flight than a different aircraft of similar size. The company also took a customer survey that found 98% of passengers said they would like to fly again on the Dreamliner.

"This is better than what we initially expected," said Kohei Tsuji, an All Nippon spokesman. "And the financial impact will only grow bigger for ANA as we continue to operate more Dreamliners."

Scott Hamilton, an aviation industry consultant and managing director of Leeham Co. in Issaquah, Wash., said that the latest Dreamliner problems are "irritants more than substance."

"The 787 problems are annoying for the airlines and embarrassing for Boeing," he said. "But I don't see these as major issues to worry about."

william.hennigan@latimes.com

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Reaction to the death of actor Jack Klugman

Celebrities on Monday reacted to the death of "Odd Couple" star Jack Klugman, who died Monday at age 90. Here are samples of sentiments expressed on Twitter:

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"R.I.P. Jack Klugman, Oscar, Quincy a man whose career spanned almost 50 years. I first saw him on the Twilight Zone. Cool guy wonderful actor." — Whoopi Goldberg.

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"You made my whole family laugh together." — Actor Jon Favreau, of "Swingers," ''Iron Man" and other films.

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"I worked with Jack Klugman several years ago. He was a wonderful man and supremely talented actor. He will be missed" — Actor Max Greenfield, of the "New Girl" on Fox.

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"So sorry to hear that Jack Klugman passed away. I learned a lot, watching him on television" — Dan Schneider, creator of Nickelodeon TV shows "iCarly," ''Drake and Josh" ''Good Burger," ''Drake & Josh."

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Corporate tax rate overhaul may be part of a 'fiscal cliff' deal

WASHINGTON — Amid the wrangling over the so-called fiscal cliff, President Obama and congressional Republicans can agree on something: They want to lower the corporate tax rate.

The U.S. has the highest overall rate of any of the world's developed economies. It took the top spot in March after Japan reduced its rate, mimicking other countries that have lowered taxes to lure new businesses and keep existing companies from leaving.

Negotiations to avert automatic income tax increases and federal spending cuts scheduled to kick in Jan. 1 could provide the impetus for U.S. policymakers to tackle an overhaul of the corporate tax code next year.

The White House wants to put a corporate tax overhaul, along with changes to the individual income tax system, on a fast track as part of any deal to avoid the "fiscal cliff."

The centerpiece of an overhaul would be slashing the 35% corporate tax rate, a goal long sought by corporate executives and lobbyists.

Quiz: How much do you know about the 'fiscal cliff'?

"In the name of global competitiveness, I think that has largely been agreed to," Jim McNerney, chief executive of Boeing Co., said about how both parties view the need for major corporate tax changes.

In February, Obama proposed lowering the federal rate to 25% for manufacturing companies and to 28% for other firms. Rep. Dave Camp (R-Mich.), chairman of the House Ways and Means Committee, has been pushing a plan to lower the rate to 25% for all corporations.

In both cases, the rate cuts would be accompanied by the elimination of some of the numerous tax breaks that allow many companies to pay a much lower effective tax rate — and sometimes to avoid paying any corporate taxes at all.

"The administration's position on this is very much in sync with what Republicans say they want, which is a lower rate and a broader base," said Jared Bernstein, a senior fellow at the Center on Budget and Policy Priorities and the former chief economist for Vice President Joe Biden.

But there still are some obstacles to a deal.

Some Democrats want to use an overhaul to increase the amount of tax revenue coming from corporations, while Republicans want to keep the amount the same. The White House and congressional Republicans also differ on how the U.S. should treat money earned abroad.

And the business community itself is divided. Many small companies file taxes as individuals. They're opposed to any "fiscal cliff" deal that would raise their rates while giving corporations a rate reduction.

Analysts said the obstacles could be overcome because there is consensus around the broader point that the U.S. needs to bring its corporate tax rate in line with other developed nations.

"Regardless of your political persuasion, it is unquestionably the case that the nominal U.S. corporate tax rate is much higher than that of peer countries," said Edward Kleinbard, a USC law professor and former chief of staff of Congress' Joint Committee on Taxation.

The case for corporate tax reform got a boost when the overall U.S. rate of 39.1%, which includes federal, state and local corporate taxes, became the highest this year among the 34 nations in the Organization for Economic Cooperation and Development. Two decades ago, the U.S. was 13th.

"At one time in the '80s, we had a competitive corporate tax rate," said Dorothy Coleman, vice president of tax and domestic economic policy for the National Assn. of Manufacturers. "We've fallen behind by standing still."

Quiz: The year in business

But the rate in the tax code isn't what many companies pay because of a host of deductions and tax credits. In 2011, the effective corporate tax rate in the U.S. was 29.2%, roughly in line with the 31.9% average of the six other largest developed economies, the Obama administration said.

The White House said that parity does not mean the statutory rate shouldn't be reduced. It simply means that many tax breaks should be eliminated, allowing the rate to be lowered without adding to the deficit.

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