Hasbro to meet with girl, 13, on gender-neutral Easy-Bake ovens









The 13-year-old New Jersey girl who started a petition for boy-friendly Easy-Bake ovens will meet Monday with Hasbro, the company that makes the kitchen toy.

In a statement, Hasbro said it invited McKenna Pope and her family to make their case at its Pawtucket, R.I., headquarters as “a consumer centric company” would.  


“Through the years, based on both market research and buying patterns, we have seen that the primary interest in the Easy-Bake Oven comes from girls,” the company said.





In the past, Hasbro has made gender neutral Easy-Bake ovens, it said.


“Clearly we believe it is a great product that can provide lots of enjoyment for both girls and boys ages 8 and up,” the company said.


Pope’s campaign began when she tried to buy an Easy-Bake oven for her gastronomically-inclined 4-year-old brother, only to discover that the product was only available in “girlie purple and pink colors,” she wrote in a petition on Change.org.


So far, more than 41,000 people have signed the petition urging Hasbro to market the product to boys as well as girls.


Pope and her brother have also garnered support from some major male bakers and chefs. In a YouTube video titled “Everyone Can Cook,” culinary celebrities such as "Top Chef" star Manuel Trevino, Joshua Whigham of the Bazaar in Beverly Hills and Michael Lomonaco of Porter House cheer on the eighth-grader’s efforts.


“Little boys and little girls can all be chefs, right?” asks Lomonaco in the video, to a roar of approval from his (mostly male) staff.



ALSO:


'Binders full of women': What's happening with the gender gap?


Eighth-grader petitions Hasbro to market Easy-Bake Ovens to boys


Women a century away from breaking California glass ceiling, study says





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Web host Go Daddy appoints former Yahoo executive as CEO






(Reuters) – Go Daddy, one of the world’s biggest Internet hosting firms, appointed Yahoo Inc‘s former Chief Product Officer Blake Irving as chief executive.


He will take over from interim CEO Scott Wagner on January 7. Irving left Yahoo, where he headed a centralized products group that straddled several client types, on April 27.






“Blake Irving’s deep technology experience and his history of developing new cutting-edge products and leading large global teams make him a … compelling choice to drive Go Daddy to the next level of its … growth,” said Bob Parsons, Go Daddy’s executive chairman and founder.


Irving also served in various positions at Microsoft Corp from 1992 to 2007.


Go Daddy, which describes itself as the top provider of domain names, filed to go public in 2006 but withdrew its IPO due to poor market conditions.


(Reporting by Neha Alawadhi in Bangalore; Editing by Joyjeet Das, Maju Samuel)


Internet News Headlines – Yahoo! News


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'Right-to-work' measure passes in Michigan Legislature









Controversial "right-to-work" legislation covering public-sector employees passed the Michigan House of Representatives on Tuesday, bringing it one step closer to being signed into law.


The House passed the bill, 58 to 51, as union opponents of the measure booed inside the Capitol and an estimated 12,000 people rallied outside. The state's Senate approved the bill last week.


The House is now scheduled to vote on a right-to-work bill for private-sector employees, which would cover Michigan's auto industry. If that measure passes, Michigan would become the 24th right-to-work state, meaning unions cannot require members to pay dues as a condition of employment.








Michigan is the fourth state in the Midwest to become embroiled in labor controversy since 2010, when a slate of Republican governors were swept into statehouses across the nation. The speed with which the right-to-work measure are being passed worries some labor experts, who say that it was once unimaginable that Michigan, where 17.5% of the workforce is unionized, would become a right-to-work state.


"Michigan could prove defining," said Harley Shaiken, a labor expert at UC Berkeley. "What happens here, given the role of unions historically in Michigan, and the larger political implications of right-to-work, will mean a lot."


But even as the Rev. Jesse Jackson rallied protesters on the steps of Lansing City Hall, labor leaders were hurriedly seeking ways to reverse the legislation down the road.


Michigan can't go the way of Ohio, where a referendum last year reversed legislation that would have restricted collective bargaining. Michigan's right-to-work legislation is attached to an appropriations bill, meaning it can't be reversed by referendum. Also, it may be too risky to wait and go the way of Wisconsin, where litigation continues after a judge struck down parts of a collective bargaining law.


However, in Michigan, there is an option of a "statutory initiative," which would be permitted if opponents of the bills can collect enough signatures to equal 8% of the votes cast in the last gubernatorial election, union leaders say. A so-called veto referendum could be triggered by collecting signatures equal to 5% of the votes cast.


A statutory initiative would allow voters to cast a ballot on right-to-work legisation in November 2014, when Gov. Rick Snyder, who has said he would support the legislation, will be up for reelection.


"There are multiple options for a referendum," a senior labor leader said Tuesday. "All options are on the table. This fight is far from over."


It’s unclear whether unions are promoting a referendum now to warn Snyder of the repercussions that signing the legislation would have.


Democrats including Sen. Carl Levin and Rep. John Dingell met with Snyder on Monday to urge him to veto the legislation. The governor promised to "seriously" consider their concerns, but Democrats remained worried that he would sign the bills.

“The governor has a choice: He can put this on the ballot, and let the voters make the determination, or he can jam it through a lame-duck session,” Dingell said Monday.


Snyder, a businessman before he became governor, was elected in 2010 by a landslide, beating his opponent by a nearly 2-to-1 margin. But only 35.5% of respondents said they thought he was doing an "excellent" or "good" job in a Michigan State University survey this fall, and that figure could fall as the controversy continues.


"I think this will pass, and be signed, and there will be a long struggle with the United Auto Workers and other unions,” said Kristin Dziczek, director of the labor and industry group at the Center for Automotive Research. "They’re going to focus their attentions on overturning this. I don’t think the war has even begun."


ALSO:


Obama blasts right-to-work in Michigan


Ohio votes to overturn new collective bargaining law

Protests re-ignite as Michigan right-to-work bill nears final OK








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Vindication for 2013 Rock Hall of Fame inductees


Randy Newman's glad he didn't have to do anything drastic to get into the Rock and Roll Hall of Fame. The members of Rush are choosing to let bygones be bygones. And Quincy Jones, well, he's still mad.


For most of this year's inductees, inclusion was a long time coming.


"I'm very happy," the 69-year-old Newman said Monday from his home in Los Angeles. "I thought I'd have to die first, but I'm glad I'm around to see it."


Newman is joined in the 2013 class by the eclectic group of rockers Rush and Heart, rap group Public Enemy, "Queen of Disco" Donna Summer and bluesman Albert King. Jones and his friend Lou Adler will enter the hall as Ahmet Ertegun Award winners for their contributions to rock beyond performance.


They will be inducted into the hall of fame April 18 in Los Angeles. The ceremony will mark the end of a long wait for fans of five of those six acts, who've been eligible for entry for some time. Public Enemy was inducted on its first ballot appearance, swelling the ranks of hip-hop entries.


In many ways, the 2013 class balances the scales, though not nearly soon enough for some new members.


"Well, it's about time, man," Jones said late Monday night in an interview from his home in Los Angeles. "But I promise you I'm not sitting around worrying about it."


Summer, who passed away at age 63 in May, gains entry after six years as a nominee. King, a deep influence on Jimi Hendrix and Stevie Ray Vaughn who died in 1992, now takes his place along all the other legendary blues guitarists in the hall.


Rush, one of the most-played staples of classic rock radio, gained entry following its first appearance on the ballot. But the Canadian trio became eligible in 1998 and was repeatedly left off the list, to the great consternation of its legion of fans who cried bias against prog rock. Heart also waited a decade to make it on the ballot, gaining entry during its second appearance.


After years of disappointment, then disinterest, Rush's Alex Lifeson said the band now feels "wonderful" about its entry into the hall and is especially happy for its followers.


"First of all it's all water under the bridge and it was a very tiny bridge," the 59-year-old guitarist said in a phone interview from his home in Toronto. "I think our fans are more upset than we were because they feel a real bond to this band and it's been an important part of their lives in some form, and to be snubbed was snubbing them at the same time. ... Perhaps there were times when I thought if this ever happens I'm not going to bother going, or who cares or whatever, but at the end of the day positive karma is an important thing and this is an important thing to a lot of our fans and people we know."


Jones was less forgiving of the long wait he had. The 79-year-old entertainment icon's fingerprints are all over the hall of fame. He pops up often at key moments in rock 'n' roll history and was even Ray Charles' presenter during the soul singer's induction at the inaugural 1986 ceremony. He never expected to wait so long for his own entry.


"I was pissed off about it at first because I saw how it was going down and who was going in and who wasn't," Jones said with a deep laugh. "But I'm used to it, man. I've been around a long time, and I know how it works, you know. It's still an honor, man."


The 2013 class also continues the process of opening the hall of fame's doors a little bit wider.


In many cases, the delayed entry of this year's inductees had to do with a debate among its membership over the hall of fame's direction. The rock 'n' roll family sits under a big tent, but just how big it should be has been a matter of debate for the Cleveland, Ohio, institution.


The class may signal a new direction.


"That is an eclectic group," Newman said. "Well that's nice. It seems like they're broadening what they think rock 'n' roll is. That's good. There's no point being doctrinaire about music. ... People get awful strict. It's a hell of a thing to get strict about, isn't it?"


There was clearly no debate among the hall's membership about Public Enemy, which gained membership on its 25th anniversary.


The openly militant, always angry group helped elevate and define nascent rap in the 1980s and '90s. MC Chuck D said the group's induction is about more than simple membership.


"It's a great piece of news for the genre and our intention was to spread the light that our music is as legitimate as any other music," Chuck D said as the group traveled through Wyoming on tour Monday. " ... So this is significant to be alongside Grandmaster Flash and The Furious Five, Run DMC and the Beastie Boys and just to be able to say this accomplishment, we don't think it's solely due to us."


Lifeson hopes the hall's membership keeps up with the trend.


"Maybe it should be the Music Hall of Fame and not so much the Rock and Roll Hall of Fame," Lifeson said. "But maybe it all is rock 'n' roll. It started as a little seed and grew into this great big tree with a lot of branches. That's why it's so sad the whole progressive movement, bands like Yes and King Crimson, are not included in this. And I hope one day that they are because they deserve to be in there way before we do. They were huge influences on us and so many other bands that have done fantastic work over the years. I know Deep Purple were up for this as well. It's a little unfortunate that they didn't make it in because they were extremely influential. I hope there comes a time when these other artists and bands are included because they were equally as influential as any of the ones that are being inducted today."


___


Online:


http://rockhall.com /


___


Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott.


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News Analysis: A Debate on Coated Aspirins and Aspirin Resistance





Millions of Americans take low-dose aspirin every day to prevent heart attacks and strokes. But a study published last week challenges some cherished beliefs about the familiar remedy, leaving some consumers to wonder if they should throw out their coated pills and others concerned that they unnecessarily may be taking expensive substitutes.




The study, published in the journal Circulation, by researchers at the University of Pennsylvania, tested 400 healthy people for evidence that aspirin did not work in them, a phenomenon called “aspirin resistance.” Aspirin prevents blood platelets from sticking together, which can lead to heart attacks and strokes. Previous studies have estimated that anywhere from 5 to 40 percent of the population is resistant to aspirin’s effects.


But the study essentially found that the condition doesn’t exist: they could not document a single case of true aspirin resistance in their sample. What had appeared to be aspirin resistance, they said, actually was caused by the coating commonly used on aspirin pills intended to protect the stomach. The coating slowed the drug’s absorption into the body.


The study didn’t evaluate whether coated aspirin was less likely to prevent heart attacks or strokes, said Dr. Garret FitzGerald, one of the authors. And people who took the coated aspirin in his study eventually showed a response to it.


But people who seek out coated aspirin may be doing so unnecessarily, he said, especially since previous studies have not consistently shown that the coating even prevents gastric problems.


“There’s no rationale for you to be on coated aspirin,” said Dr. FitzGerald, who is a cardiologist and chairman of pharmacology at the University of Pennsylvania.


Some cardiologists have begun advising patients to seek out uncoated aspirin because other studies have suggested that the uncoated type may be more effective. But finding it isn’t so easy. Even cheaper store brands, like those sold by CVS and Wal-Mart, come with a so-called enteric coating. One of the few uncoated aspirins on the market is St. Joseph’s chewable variety — the old orange-flavored baby aspirin.


But other experts, like Dr. Steven E. Nissen, a cardiologist at the Cleveland Clinic, see no real harm in taking coated aspirin, which is cheap and readily available. Many major studies of aspirin have been conducted using the coated variety.


The new study also calls into question the very idea of aspirin resistance. Testing for the condition became more widespread in the early 2000s, as expensive prescription alternatives like the blood thinner Plavix (also called clopidogrel) gained popularity. Many cardiologists suspected that the timing was not a coincidence.


“Before clopidogrel, we had never heard of aspirin resistance,” said Dr. Sanjay Kaul, a cardiologist at Cedars-Sinai Medical Center in Los Angeles. “It seemed to be that this was driven mostly by marketing considerations.” The new study raises the possibility that many patients may have been falsely told that aspirin doesn’t work on them, Dr. Kaul and other experts said.


The University of Pennsylvania study was partially financed by Bayer, the world’s largest manufacturer of branded aspirin, much of which is coated. In a statement, Bayer challenged some of the study’s conclusions and methods, and also said there was evidence that the enteric coating can reduce gastric side effects.


Critics of Dr. FitzGerald’s study also argue that he should have studied aspirin resistance in patients with conditions like heart disease, rather than in healthy people.


But even these critics acknowledge that testing for resistance is probably not worthwhile. Dr. Nissen, who is critical of Dr. FitzGerald’s study, doesn’t test his patients for aspirin resistance. But he said he would be reluctant to switch a patient from another drug back to aspirin now if a test had previously shown they were aspirin-resistant. Changing treatments is always risky, he said.


“If the patient is not bleeding, is not having a complication, am I going to take it away?” Dr. Nissen wondered. “That’s the dilemma we face.”


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Index of California consumer sentiment falls slightly in quarter













Rodeo Drive


Consumer confidence in California fell slightly in the last three months of 2012 but remains near its highest level since the start of the recession, according to a Chapman University index. Above, shoppers visit Rodeo Drive in Beverly Hills..
(Patrick Fallon / Bloomberg)































































Consumer confidence in California weakened slightly in the fourth quarter of this year, according to a Chapman University index released Tuesday.


The California Composite Index of Consumer Confidence decreased to 92.7 from a revised third-quarter reading of 93.4, which was its highest level since the recession, according to the university.


Despite the latest decline, the index shows consumer confidence has been steadily rising as the labor market has improved.





The index of current economic conditions, a component of the overall index, was 80.6 in the fourth quarter, down nearly four points from a third-quarter reading of 84.2.


The biggest drop was in the index measuring consumers' confidence in future economic conditions, which fell to 98.6 from 105.


That slide probably reflects consumers' worries about the looming "fiscal cliff" -- the year-end federal tax increases and spending cuts scheduled to take effect if Congress does not take action, Chapman economists said. The passage of Proposition 30 in California, which will increase state taxes, also has apparently dampened consumer sentiment.

The index of future spending plans, however, showed a surge in consumers' willingness to spend on big-ticket items such as electronics and appliances.  The index rose 17 points to 105.4 from 88.4.


ALSO:


'Right-to-work' measure passes in Michigan Legislature


'Obamacare,' fiscal cliff leads to small business optimism plunge


Despite ports strike, U.S. cargo volume to rise 3.9% in December


ricardo.lopez2@latimes.com


Follow Ricardo Lopez on Twitter.






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Latin music star Jenni Rivera believed dead in plane crash

Fans of Mexican-American singing star Jenni Rivera held a vigil Sunday night in Lynwood









MEXICO CITY — Mexican American singer Jenni Rivera, the "diva de la banda" whose commanding voice burst through the limits of regional Latin music and made her a cross-border sensation and the queen of a business empire, was believed to have died Sunday when the small jet carrying her and members of her entourage crashed in mountainous terrain.


Rivera, a native of Long Beach, was 43. Mexico's ministry of transportation did not confirm her death outright, but it said that she had been aboard the plane and that no one had survived the crash. Six others, including two pilots, also were on board.


"Everything suggests, with the evidence that's been found, that it was the airplane that the singer Jenni Rivera was traveling in," said Gerardo Ruiz Esparza, Mexico's secretary of communications and transportation. Of the crash site, Ruiz said: "Everything is destroyed. Nothing is recognizable."








Word of the accident ricocheted around the entertainment industry, with performer after performer expressing shock and grief. Fans gathered outside Rivera's four-acre estate in Encino.


"She was the Diana Ross of Mexican music," said Gustavo Lopez, an executive vice president at Universal Music Latin Entertainment, an umbrella group that includes Rivera's label. Lopez called Rivera "larger than life" and said that based on ticket sales, she was by far the top-grossing female artist in Mexico.


"Remember her with your heart the way she was," her father, Don Pedro Rivera, told reporters in Spanish on Sunday evening. "She never looked back. She was a beautiful person with the whole world."


Rivera had performed a concert in Monterrey, Mexico, on Saturday night — her standard fare of knee-buckling power ballads, pop-infused interpretations of traditional banda music and dizzying rhinestone costume changes.


At a news conference after the show, Rivera appeared happy and tranquil, pausing at one point to take a call on her cellphone that turned out to be a wrong number. She fielded questions about struggles in her personal life, including her recent separation from husband Esteban Loaiza, a professional baseball player.


"I can't focus on the negative," she said in Spanish. "Because that will defeat you. That will destroy you.... The number of times I have fallen down is the number of times I have gotten up."


Hours later, shortly after 3 a.m., Rivera is believed to have boarded a Learjet 25, which took off under clear skies. The jet headed south, toward Toluca, west of Mexico City; there, Rivera had been scheduled to tape the television show "La Voz" — Mexico's version of "The Voice" — on which she was a judge.


The plane, built in 1969 and registered to a Las Vegas talent management firm, reached 11,000 feet. But 10 minutes and 62 miles into the flight, air traffic controllers lost contact with its pilots, according to Mexican authorities. The jet crashed outside Iturbide, a remote city that straddles one of the few roads bisecting Mexico's Sierra de Arteaga national park.


Wreckage was scattered across several football fields' worth of terrain. An investigation into the cause of the crash was underway, and attempts to identify the remains of the victims had begun.


Rivera, a mother of five and grandmother of two, was believed to have been traveling with her publicist Arturo Rivera, who was not related to her, as well as with her lawyer, hairstylist and makeup artist; reports of their names were not consistent. Their identities were not confirmed by authorities. The pilots were identified as Miguel Perez and Alejandro Torres.


In the world of regional Latin music — norteño, cumbia and ranchera are among the popular niches — Rivera was practically royalty.


Her father was a noted singer of the Mexican storytelling ballads known as corridos. In the 1980s he launched the record label Cintas Acuario. It began as a swap-meet booth and grew into an influential and taste-making independent outfit, fueling the careers of artists such as the late Chalino Sanchez. Jenni Rivera's four brothers were associated with the music industry; her brother Lupillo, in particular, is a huge star in his own right.


Born on July 2, 1969, Rivera initially showed little inclination to join the family business. She worked for a time in real estate. But after a pregnancy and a divorce, she went to work for her father's record label and found her voice, literally and figuratively.


She released her first studio album in 2003, when she was 34.


Her path had not been easy, but rather than running from it, she wrote it into her music — domestic violence; struggles with weight; raising her children alone, or "sin capitan," without a captain. She was known for marathon live shows that left audiences exhilarated and exhausted; by the fifth hour of one recent performance, she was drinking straight from a tequila bottle and launching into a cover of "I Will Survive."


In a witty and sometimes baffling stew of Spanish and English, she sang about her three husbands, about drug traffickers, in tribute to her father, in tribute to her gynecologist.


She became, in a most unlikely way, a feminist hero among Latin women in Mexico and the United States and a powerful player in a genre of music dominated by men and machismo. Regional Mexican music styles had long been seen as limiting to artists, but Rivera shrugged off the labels and brought traditional-laced music — some of which sounded perilously close to polka — to a massive pop audience.





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'Zero Dark Thirty,' 'Lincoln' make AFI top-10 list


LOS ANGELES (AP) — Kathryn Bigelow's Osama bin Laden thriller "Zero Dark Thirty," Steven Spielberg's Civil War epic "Lincoln" and Christopher Nolan's superhero tale "The Dark Knight Rises" are among the American Film Institute's top-10 movies of the year.


Also on the AFI top-10 announced Monday: Ben Affleck's Iran hostage-crisis drama "Argo;" Benh Zeitlin's low-budget hit "Beasts of the Southern Wild;" Quentin Tarantino's slavery saga "Django Unchained;" Tom Hooper's Victor Hugo musical "Les Miserables;" Ang Lee's shipwreck story "Life of Pi;" Wes Anderson's first-love romance "Moonrise Kingdom;" and David O. Russell's misfit love story "Silver Linings Playbook."


The AFI also picked its top-10 TV shows for the year: "American Horror Story;" ''Breaking Bad;" ''Game Change;" ''Game of Thrones;" ''Girls;" ''Homeland;" ''Louie;" ''Mad Men;" ''Modern Family;" and "The Walking Dead."


Creative ensembles for the films and TV shows will be honored at a luncheon in Los Angeles on Jan. 11.


___


Online:


http://www.afi.com


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A Breakthrough Against Leukemia Using Altered T-Cells





PHILIPSBURG, Pa. — Emma Whitehead has been bounding around the house lately, practicing somersaults and rugby-style tumbles that make her parents wince.




It is hard to believe, but last spring Emma, then 6, was near death from leukemia. She had relapsed twice after chemotherapy, and doctors had run out of options.


Desperate to save her, her parents sought an experimental treatment at the Children’s Hospital of Philadelphia, one that had never before been tried in a child, or in anyone with the type of leukemia Emma had. The experiment, in April, used a disabled form of the virus that causes AIDS to reprogram Emma’s immune system genetically to kill cancer cells.


The treatment very nearly killed her. But she emerged from it cancer-free, and about seven months later is still in complete remission. She is the first child and one of the first humans ever in whom new techniques have achieved a long-sought goal — giving a patient’s own immune system the lasting ability to fight cancer.


Emma had been ill with acute lymphoblastic leukemia since 2010, when she was 5, said her parents, Kari and Tom. She is their only child.


She is among just a dozen patients with advanced leukemia to have received the experimental treatment, which was developed at the University of Pennsylvania. Similar approaches are also being tried at other centers, including the National Cancer Institute and Memorial Sloan-Kettering Cancer Center in New York.


“Our goal is to have a cure, but we can’t say that word,” said Dr. Carl June, who leads the research team at the University of Pennsylvania. He hopes the new treatment will eventually replace bone-marrow transplantation, an even more arduous, risky and expensive procedure that is now the last hope when other treatments fail in leukemia and related diseases.


Three adults with chronic leukemia treated at the University of Pennsylvania have also had complete remissions, with no signs of disease; two of them have been well for more than two years, said Dr. David Porter. Four adults improved but did not have full remissions, and one was treated too recently to evaluate. A child improved and then relapsed. In two adults, the treatment did not work at all. The Pennsylvania researchers were presenting their results on Sunday and Monday in Atlanta at a meeting of the American Society of Hematology.


Despite the mixed results, cancer experts not involved with the research say it has tremendous promise, because even in this early phase of testing it has worked in seemingly hopeless cases. “I think this is a major breakthrough,” said Dr. Ivan Borrello, a cancer expert and associate professor of medicine at the Johns Hopkins University School of Medicine.


Dr. John Wagner, the director of pediatric blood and marrow transplantation at the University of Minnesota, called the Pennsylvania results “phenomenal” and said they were “what we’ve all been working and hoping for but not seeing to this extent.”


A major drug company, Novartis, is betting on the Pennsylvania team and has committed $20 million to building a research center on the university’s campus to bring the treatment to market.


Hervé Hoppenot, the president of Novartis Oncology, called the research “fantastic” and said it had the potential — if the early results held up — to revolutionize the treatment of leukemia and related blood cancers. Researchers say the same approach, reprogramming the patient’s immune system, may also eventually be used against tumors like breast and prostate cancer.


To perform the treatment, doctors remove millions of the patient’s T-cells — a type of white blood cell — and insert new genes that enable the T-cells to kill cancer cells. The technique employs a disabled form of H.I.V. because it is very good at carrying genetic material into T-cells. The new genes program the T-cells to attack B-cells, a normal part of the immune system that turn malignant in leukemia.


The altered T-cells — called chimeric antigen receptor cells — are then dripped back into the patient’s veins, and if all goes well they multiply and start destroying the cancer.


The T-cells home in on a protein called CD-19 that is found on the surface of most B-cells, whether they are healthy or malignant.


A sign that the treatment is working is that the patient becomes terribly ill, with raging fevers and chills — a reaction that oncologists call “shake and bake,” Dr. June said. Its medical name is cytokine-release syndrome, or cytokine storm, referring to the natural chemicals that pour out of cells in the immune system as they are being activated, causing fevers and other symptoms. The storm can also flood the lungs and cause perilous drops in blood pressure — effects that nearly killed Emma.


Steroids sometimes ease the reaction, but they did not help Emma. Her temperature hit 105. She wound up on a ventilator, unconscious and swollen almost beyond recognition, surrounded by friends and family who had come to say goodbye.


But at the 11th hour, a battery of blood tests gave the researchers a clue as to what might help save Emma: her level of one of the cytokines, interleukin-6 or IL-6, had shot up a thousandfold. Doctors had never seen such a spike before and thought it might be what was making her so sick.


Dr. June knew that a drug could lower IL-6 — his daughter takes it for rheumatoid arthritis. It had never been used for a crisis like Emma’s, but there was little to lose. Her oncologist, Dr. Stephan A. Grupp, ordered the drug. The response, he said, was “amazing.”


Within hours, Emma began to stabilize. She woke up a week later, on May 2, the day she turned 7; the intensive-care staff sang “Happy Birthday.”


Since then, the research team has used the same drug, tocilizumab, in several other patients.


In patients with lasting remissions after the treatment, the altered T-cells persist in the bloodstream, though in smaller numbers than when they were fighting the disease. Some patients have had the cells for years.


Dr. Michel Sadelain, who conducts similar studies at the Sloan-Kettering Institute, said: “These T-cells are living drugs. With a pill, you take it, it’s eliminated from your body and you have to take it again.” But T-cells, he said, “could potentially be given only once, maybe only once or twice or three times.”


The Pennsylvania researchers said they were surprised to find any big drug company interested in their work, because a new batch of T-cells must be created for each patient — a far cry from the familiar commercial strategy of developing products like Viagra or cholesterol medicines, in which millions of people take the same drug.


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Holiday retail hiring could break record set 12 years ago









Holiday hiring by retailers is fast approaching a record set 12 years ago, according to a new analysis of government numbers.


So far, retailers have added 619,700 seasonal workers in October and November, 19% more than the 512,600 holiday employees hired over the same period last year, according to consultancy firm Challenger, Gray & Christmas Inc.


If businesses bring on just 140,300 more workers in December, they’ll match the nearly 760,000 employees tacked on to payrolls during the three-month holiday hiring season in 2000 – a record high.





Doing so isn’t a stretch. Last year, retailers hired 147,600 workers in December, bringing the three-month total to 660,200 seasonal employees.


Last month, businesses such as Target and Amazon.com picked up 465,500 additional workers -- a 21% increase from a year ago and slightly above the record set in November 2007. Challenger derives its non-seasonally adjusted data from the Bureau of Labor Statistics.


“Despite all of the uncertainty, all the talk of fiscal cliffs, the widespread damage to retail epicenters on the east coast by Hurricane Sandy, and the continued growth of e-commerce, retailers are hiring holiday workers in record numbers,” said Chief Executive John A. Challenger in a statement.


The influx of workers is being used to staff stores as they expand holiday hours. Chains such as Wal-Mart caused a kerfuffle as they opened even before Black Friday, allowing shoppers in on Thanksgiving. Macy’s stores will stay open for 48 hours straight starting Dec. 21, with 57 stores keeping the lights on for another 24 hours after that.


But whether the hordes of retail associates will be met with crowds of shoppers is unclear. Consumer confidence is at a four-month low. Though Black Friday saw healthy shopping levels, retail sales overall rose a weak 1.6% in November.


ALSO:


Retail sales rise a weak 1.6% in November


Consumer confidence falls sharply amid 'fiscal cliff' worries


Macy's will open doors 48 hours straight before Christmas





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